Impact of IgE sensitization and rhinitis on inflammatory biomarkers and lung function in adolescents with and without asthma.

Jenny HallbergNatalia BallardiniCatarina AlmqvistMarit WestmanMarianne van HageGunnar LiljaAnna BergströmInger KullErik Melén

Published in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2018)

We found signs of peripheral airway obstruction and increased levels of inflammatory biomarkers in the presence of allergic asthma, irrespective of rhinitis status. Despite having a reduced FEV1 /FVC, peripheral airway engagement was not seen in non-sensitized adolescents with asthma. We suggest that small airway disease is a feature related to the eosinophilic inflammation in allergic asthma in adolescence.

Keyphrases

lung function
chronic obstructive pulmonary disease
allergic rhinitis
cystic fibrosis
air pollution
young adults
oxidative stress
machine learning
depressive symptoms