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Cu-Catalyzed Denitrogenative Ring-Opening of 3-Aminoindazoles for the Synthesis of Aromatic Nitrile-Containing (Hetero)Arenes.

Yao ZhouShuilin DengShaoyu MaiQiuling Song
Published in: Organic letters (2018)
An unprecedented Cu-catalyzed oxidative cleavage of two C-N bonds of 3-aminoindazoles is reported herein, which represents the first example for denitrogenative ring-opening of 3-aminoindazoles. This novel reactivity of 3-aminoindazoles enables the production of diverse aromatic nitrile-containing (hetero)arenes via C-H arylation of (hetero)arenes with wide subsrate scope under mild conditions.
Keyphrases
  • room temperature
  • amino acid
  • aqueous solution
  • metal organic framework
  • dna binding
  • ionic liquid