Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity.

Yu Hee LeeHye Sook JungMin Jeong KwonJung Eun JangTae Nyun Kim Yeong-Min LeeMi-Kyung KimJeong Hyun Park

Published in: Islets (2020)

Melatonin protected pancreatic β-cell from apoptosis, decreased expressions of the markers related to the accelerated senescence, and improved the biological deteriorations induced by glucotoxicity and glucolipotoxicity.

Keyphrases

oxidative stress
cell cycle arrest
endoplasmic reticulum stress
dna damage
cell death
endothelial cells
single cell
stress induced
stem cells
pi k akt
signaling pathway
cell proliferation