Prognostic Role of Targeted Methylation Analysis in Paraffin-embedded Samples of Adrenocortical Carcinoma.

Juliane LippertBarbara AltieriBreanna MorrisonSonja SteinhauerGabrielle SmithAntonia LoreyHanna UrlaubStefan KircherAlice SitchFassnacht Martin Cristina L Ronchi

Published in: The Journal of clinical endocrinology and metabolism (2022)

This study demonstrated that hypermethylation in PAX5 is associated with worst clinical outcome in ACC, even after accounting for S-GRAS score. Assessing methylation in FFPE material is straightforward in the clinical setting and could be used to improve accuracy of prognostic classification, enabling the direction of personalized management.

Keyphrases

genome wide
dna methylation
machine learning
cancer therapy
drug delivery
transcription factor