Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.

Jacqueline G GerhartFernando O CarreñoAndrea N EdgintonJaydeep SinhaEliana M PerrinKaran R KumarAruna RikhiChristoph P HornikVincent HarrisSamit GangulyMichael Cohen-WolkowiezDaniel Gonzaleznull null

Published in: Clinical pharmacokinetics (2021)

Model simulations support current recommended weight-based dosing in children with obesity for clindamycin and trimethoprim/sulfamethoxazole, as they met target exposure despite these changes in clearance and volume of distribution.

Keyphrases

weight loss
weight gain
insulin resistance
metabolic syndrome
young adults
type diabetes
high fat diet induced
body mass index
physical activity
monte carlo