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Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.

Jacqueline G GerhartFernando O CarreñoAndrea N EdgintonJaydeep SinhaEliana M PerrinKaran R KumarAruna RikhiChristoph P HornikVincent HarrisSamit GangulyMichael Cohen-WolkowiezDaniel Gonzaleznull null
Published in: Clinical pharmacokinetics (2021)
Model simulations support current recommended weight-based dosing in children with obesity for clindamycin and trimethoprim/sulfamethoxazole, as they met target exposure despite these changes in clearance and volume of distribution.
Keyphrases
  • weight loss
  • weight gain
  • insulin resistance
  • metabolic syndrome
  • young adults
  • type diabetes
  • high fat diet induced
  • body mass index
  • physical activity
  • monte carlo