Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.
Jacqueline G GerhartFernando O CarreñoAndrea N EdgintonJaydeep SinhaEliana M PerrinKaran R KumarAruna RikhiChristoph P HornikVincent HarrisSamit GangulyMichael Cohen-WolkowiezDaniel Gonzaleznull nullPublished in: Clinical pharmacokinetics (2021)
Model simulations support current recommended weight-based dosing in children with obesity for clindamycin and trimethoprim/sulfamethoxazole, as they met target exposure despite these changes in clearance and volume of distribution.