Rheumatoid arthritis and idiopathic pulmonary fibrosis: a bidirectional Mendelian randomisation study.
Olivia C LeavyLeticia Kawano-DouradoIain D StewartJennifer Kathleen QuintJoshua J SolomonRaphael BorieBruno CrestaniLouise V WainR Gisli JenkinsPhilippe DieudéCosetta MinelliPublished in: Thorax (2024)
Our findings support the hypothesis that RA-UIP may be due to a cause-effect relationship between UIP and RA, rather than due to a coincidental occurrence of IPF in patients with RA. The significant causal effect of IPF on seropositive RA suggests that pathomechanisms involved in the development of UIP may promote RA, and this may help inform future guidelines on screening for ILD in patients with RA.