The potential role of regulatory microRNAs of RAS/MAPK signaling pathway in the pathogenesis of colorectal cancer.
Atena SoleimaniFarzad RahmaniNikoo SaeediRana GhaffarianMajid KhazaeiGordon A FernsSoodabeh ShahidsalesSeyed Mahdi HassanianPublished in: Journal of cellular biochemistry (2019)
Colorectal cancer (CRC) is the leading cause of cancer death worldwide. Dysregulation of RAS/MAPK signaling axis is frequently found in CRC patients. The RAS/MAPK axis regulates cancer cell proliferation, apoptosis, inflammation, migration, and metastasis. Oncogenic or tumor-suppressor microRNAs (miRNAs) for RAS/MAPK signaling play a key role in the pathogenesis of CRC and are considered as novel potential biomarkers for diagnosis and prognosis of human malignancies. This review summarizes the current knowledge of mechanisms of action of RAS/MAPK miRNAs in the development and progression of CRC for a better understanding and hence a better management of this disease.
Keyphrases
- signaling pathway
- pi k akt
- oxidative stress
- wild type
- cell proliferation
- cell cycle arrest
- papillary thyroid
- induced apoptosis
- epithelial mesenchymal transition
- end stage renal disease
- healthcare
- ejection fraction
- squamous cell
- newly diagnosed
- transcription factor
- endothelial cells
- chronic kidney disease
- prognostic factors
- squamous cell carcinoma
- cell cycle
- peritoneal dialysis
- lymph node metastasis
- induced pluripotent stem cells