Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3 T3-L1 cells.
Hsin-Hsueh ShenChien-Yi YangChing-Wen KungShu-Ying ChenHong-Min WuPao-Yun ChengKwok-Keung LamYen-Mei LeePublished in: Journal of biomedical science (2019)
Distinct activation of canonical β-catenin on inhibition of adipogenesis and non-canonical SFRP5 on suppression of WAT inflammation may contribute to the beneficial effects of RAL. Therefore, this study provides a rationale for the therapeutic potential of RAL for postmenopausal obesity.
Keyphrases
- adipose tissue
- high fat diet induced
- oxidative stress
- insulin resistance
- induced apoptosis
- cell proliferation
- metabolic syndrome
- type diabetes
- stem cells
- cell cycle arrest
- weight loss
- high fat diet
- epithelial mesenchymal transition
- bone mineral density
- endoplasmic reticulum stress
- weight gain
- skeletal muscle
- signaling pathway
- physical activity
- cell death
- body mass index
- postmenopausal women