Adipocytes secretome from normal and tumor breast favor breast cancer invasion by metabolic reprogramming.
Maurice ZaouiMehdi MorelLila LouadjNathalie FerrandAntonin LamazièreCatherine UzanGeoffroy CanlorbeMichael AtlanMichèle SabbahPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2022)
We conclude that among secreted factors analyzed, only arachidonic acid and leptin levels did discriminate ASCs from tumor-bearing and tumor-free breasts emphasizing the importance that other cell types could contribute to the adipose tissue secretome in a tumor context.