Population pharmacokinetics and target attainment analyses to identify a rational empirical dosing strategy for cefepime in critically ill patients.
Guohua AnC Buddy CreechNan WuRoger L NationKenan GuDemet NalbantNatalia Jimenez-TruqueWilliam FissellPratish C PatelNicholas FishbaneAmy WatanabeStephanie L RolsmaCarl M J KirkpatrickCornelia B LandersdorferPatricia WinokurPublished in: The Journal of antimicrobial chemotherapy (2023)
Continuous infusion may represent a promising strategy for cefepime treatment in critically ill patients. With the availability of institution- and/or unit-specific cefepime susceptibility patterns as well as individual patients' renal function, our PTA results may represent useful references for physicians to make dosing decisions.