Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19.
Leonoor S BoersFrank van Someren GréveJarne M van HattemJustin de BrabanderTom ZwaanHugo van WilligenMarion CornelissenMenno de JongTom van der PollJanWillem DuitmanJanke SchinkelLieuwe D J Bosnull nullPublished in: Intensive care medicine (2024)
In mechanically ventilated COVID-19 patients, HSV reactivations are common, while CMV reactivations were rare. HSV viral load dynamics prior to or without antiviral treatment are associated with mortality. Alveolar inflammation is elevated after HSV reactivation.
Keyphrases
- herpes simplex virus
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- sars cov
- mechanical ventilation
- coronavirus disease
- oxidative stress
- pulmonary hypertension
- cardiovascular events
- intensive care unit
- combination therapy
- type diabetes
- coronary artery disease
- respiratory syndrome coronavirus