E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension.
Dan YiBin LiuHongxu DingShuai LiRebecca LiJiakai PanKarina RamirezXiaomei XiaMrinalini KalaQinmao YeWon Hee LeeRichard Eugene FryeTing WangYutong ZhaoKenneth S KnoxChristopher C GlembotskiMichael B FallonZhiyu DaiPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
Our study demonstrated that endothelial SOX17 deficiency induces pulmonary hypertension through E2F1. Thus, targeting E2F1 signaling represents a promising approach in patients with PAH.