Unusual manifestations of diffuse-type tenosynovial giant cell tumor in two patients: importance of radiologic-pathologic correlation.
Ayca DundarJason R YoungDoris E WengerCarrie Y InwardsStephen M BroskiPublished in: Skeletal radiology (2019)
Diffuse-type tenosynovial giant cell tumor (TSGCT) is a rare, locally aggressive neoplasm. It most commonly occurs in the knee, followed by the hip, and has distinctive imaging features, including mass-like foci of low T2 signal intensity, "blooming" on gradient-echo MRI, and pronounced uptake on FDG PET/CT. Histologically, TSGCT demonstrates a neoplastic population of mononuclear cells admixed with hemosiderin-laden macrophages, foamy histiocytes, inflammatory cells, and osteoclast-like giant cells. In cases where diffuse-type TSGCT presents in an uncommon location or with atypical features, the imaging diagnosis may be challenging. Furthermore, because of its polymorphous appearance, it may be mistaken microscopically for other neoplastic and non-neoplastic histiocytic lesions. Herein, we present two cases of diffuse-type TSGCT presenting as large masses, and underscore the importance of radiologic-pathologic correlation for accurate diagnosis.
Keyphrases
- giant cell
- induced apoptosis
- low grade
- cell cycle arrest
- high resolution
- end stage renal disease
- magnetic resonance imaging
- endoplasmic reticulum stress
- newly diagnosed
- neoadjuvant chemotherapy
- contrast enhanced
- squamous cell carcinoma
- ejection fraction
- chronic kidney disease
- locally advanced
- prognostic factors
- signaling pathway
- peritoneal dialysis
- mass spectrometry
- knee osteoarthritis
- high intensity
- lymph node
- peripheral blood