Deconvolution of sarcoma methylomes reveals varying degrees of immune cell infiltrates with association to genomic aberrations.

Malte SimonSadaf S MughalPeter HorakSebastian UhrigJonas BuchlohBogac AybeyAlbrecht StenzingerHanno GlimmStefan FröhlingBenedikt BrorsCharles D Imbusch

Published in: Journal of translational medicine (2021)

In summary, we have leveraged unsupervised methylation-based deconvolution to characterize the immune compartment and molecularly stratify subtypes in STS, which may benefit precision medicine in the future.

Keyphrases

copy number
genome wide
machine learning
current status
dna methylation