Significance of the angiotensin I/angiotensin II/angiotensin-(1-7) axis in the pathogenesis of systemic sclerosis.

Bartosz Miziołek Beata Bergler-CzopE KucharzP KotylaM Kopeć-MędrekM WiduchowskaMarcin SienczykL Brzezińska-Wcisło

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2019)

Production of angiotensin-(1-7) was significantly reduced in both SSc patients and those ones with very early SSc, although a significant imbalance between angiotensin II and angiotensin-(1-7) occurred only in subjects with established disease.

Keyphrases

angiotensin ii
angiotensin converting enzyme
systemic sclerosis
vascular smooth muscle cells
interstitial lung disease
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease