The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity.

Giuseppina Rosaria UmanoGrazia CirilloGianmaria SanchezGiulia RondinelliMaria Vittoria FoderiniSerena FerraraAnna Di SessaPierluigi MarzuilloAlfonso PapparellaNicola SantoroEmanuele Miraglia Del Giudice

Published in: Obesity (Silver Spring, Md.) (2023)

The lncOb rs10487505 polymorphism affects leptin circulating levels, worsens insulin resistance, and heightens the risk of prediabetes in children and adolescents with obesity.

Keyphrases

insulin resistance
high fat diet induced
metabolic syndrome
type diabetes
adipose tissue
skeletal muscle
high fat diet
weight loss
polycystic ovary syndrome