Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions.

One-third of the excitatory inputs to D1-SPNs project to D2-SPNs, while two-third of the excitatory inputs to D2-SPNs also target D1-SPNsActivation of D1-SPN projecting cortical neurons triggers behavioral effects in line with postsynaptic striatal direct pathway activationActivation of D2-SPN projecting cortical neurons causes behavioral effects similar with co-activation of both direct and indirect pathwaysCorticostriatal subcircuits control actions in a brain-region and pathway-specific manner.