Islet-antigen reactive B cells display a unique phenotype and BCR repertoire in autoantibody positive and recent-onset type 1 diabetes patients.

Catherine A NicholasFatima A TensunSpencer A EvansKevin P TooleHali BroncuciaJay R HesselberthPeter A GottliebKristen L Wells John C Cambier

Published in: bioRxiv : the preprint server for biology (2024)

Pancreatic islet antigen-reactive B cells from individuals with prediabetes and recently diagnosed with type 1 diabetes display a unique phenotype and BCR repertoire compared to non-diabetic donors.

Keyphrases

type diabetes
acute lymphoblastic leukemia
end stage renal disease
tyrosine kinase
ejection fraction
chronic kidney disease
newly diagnosed
cardiovascular disease
chronic myeloid leukemia
prognostic factors
insulin resistance
metabolic syndrome
high throughput sequencing
weight loss
patient reported