Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome.
Hassan AbolhassaniNils LandegrenPaul BastardMarie MaternaMohammadreza ModaresiLikun DuMaribel Aranda-GuillénFabian SardhFanglei ZuoPeng ZhangHarold MarcotteNico MarrTaushif KhanManar AtaFatima Al-AliRemi PescarmonaAlexandre BelotVivien BéziatQian ZhangJean-Laurent CasanovaOlle KämpeShen-Ying ZhangLennart HammarströmQiang Pan-HammarströmPublished in: Journal of clinical immunology (2022)
Our findings confirm that impaired type I IFN immunity can underlie critical COVID-19 pneumonia, while suggesting that it can also unexpectedly underlie concomitant MIS-C. Our report further raises the possibility that inherited or acquired dysregulation of type I IFN immunity might contribute to MIS-C in other patients.