Circulating uncarboxylated matrix Gla protein in patients with atrial fibrillation or heart failure with preserved ejection fraction.
Neshe Ferahova Nazifova-TasinovaAtanas Angelov AtanasovMilena Gincheva PashevaYoto Trifonov YotovDaniela Ivanova GerovaDeyana Georgieva VankovaMiglena Nikolaeva TodorovaDiana Georgieva IvanovaYoana Dimitrova Kiselova-KanevaBistra Tzaneva GalunskaPublished in: Archives of physiology and biochemistry (2020)
Context: Circulating uncarboxylated matrix Gla protein (ucMGP) is possibly related to coronary arterial calcification (CAC) in cardiovascular disease (CVD) patients.Objective: We aimed to evaluate the relationships between circulating ucMGP, CVD pathology and CAC and its interplay with CVD risk factors.Materials and methods: ucMGP was measured in 99 CVD-patients. CAC score was determined by multislice computed tomography. Circulating ucMGP, uncarboxylated (ucOC) and carboxylated osteocalcin (cOC) were assayed by ELISA kits. Vitamin-K status was evaluated by ucOC/cOC ratio.Results: A tendency for decreased ucMGP was observed for CAC ≥ 100 AU vs. CAC = 1-99 AU after exclusion of the patients on vitamin K-antagonist anticoagulants. Significant inverse correlations between ucMGP and vitamin-K status were indicated for the entire cohort and according to CAC score. Significant associations were found between ucMGP and risk factors for CVD.Conclusion: Circulating ucMGP may reflect certain stages of CVD and CAC. Future studies are needed to clarify its role as potential biomarker.
Keyphrases
- end stage renal disease
- cardiovascular disease
- computed tomography
- chronic kidney disease
- ejection fraction
- newly diagnosed
- risk factors
- peritoneal dialysis
- prognostic factors
- coronary artery disease
- magnetic resonance imaging
- type diabetes
- heart failure
- coronary artery
- patient reported outcomes
- gold nanoparticles
- small molecule
- positron emission tomography
- cardiovascular events
- binding protein
- transcatheter aortic valve replacement
- monoclonal antibody
- reduced graphene oxide
- image quality