Cerebrospinal fluid findings in adult patients with obsessive-compulsive disorder: A retrospective analysis of 54 samples.

Benjamin PankratzKatharina von ZedtwitzKimon RungeDominik DenzelKathrin NickelAndrea SchlumpKaroline PitschSimon MaierRick DerschUlrich VoderholzerKatharina Domschke Ludger Tebartz van Elst Miriam A Schiele Harald Prüss Dominique Endres

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2022)

While elevated CSF protein is merely a weak indicator of blood CSF barrier dysfunction, the presence of inflammatory CSF changes and novel brain autoantibodies in CSF may indicate OCD subtypes with inflammatory pathomechanism and supports the hypothesis of a rare "autoimmune OCD" subtype.

Keyphrases

obsessive compulsive disorder
cerebrospinal fluid
deep brain stimulation
oxidative stress
systemic lupus erythematosus
multiple sclerosis
white matter
resting state
brain injury
subarachnoid hemorrhage
cerebral ischemia