Successful treatment of established heart failure in mice with recombinant HDL (Milano).

Joseph Pierre AboumsallemMudit MishraRuhul AminIlayaraja MuthuramuHerman KempenBart De Geest

Published in: British journal of pharmacology (2018)

MDCO-216 improves diastolic function, induces regression of interstitial fibrosis and normalizes lung weight in mice with established heart failure. Recombinant HDL may emerge as a treatment modality in heart failure.

Keyphrases

heart failure
left ventricular
high fat diet induced
cardiac resynchronization therapy
acute heart failure
atrial fibrillation
body mass index
blood pressure
weight loss
type diabetes
cell free
weight gain
metabolic syndrome
ejection fraction
combination therapy
skeletal muscle
liver fibrosis