Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation.
Luz Del Carmen Martínez-SánchezPhuong Anh NgoRashmita PradhanLukas-Sebastian BeckerDavid BoehringerDespina SoteriouMarketa KubankovaChristine SchweitzerTatyana KochVeronika ThonnLena ErkertIris StolzerClaudia GüntherChristoph BeckerBenno WeigmannMonika KlewerChristoph DanielKerstin AmannStefan TenzerRaja AtreyaMartin BergoCord BrakebuschAlastair J M WatsonJochen GuckBen FabryImke AtreyaMarkus Friedrich NeurathRocío López-PosadasPublished in: Gut (2022)
Impaired epithelial RAC1 function causes cell overcrowding and epithelial leakage thus inducing chronic intestinal inflammation. Epithelial RAC1 emerges as key regulator of cytoskeletal dynamics, cell mechanics and intestinal cell shedding. Modulation of RAC1 might be exploited for restoration of epithelial integrity in the gut of patients with IBD.