Synthesis of 4-trifluoromethyl-2 H -chromenes via the reaction of 2-(trifluoroacetyl)phenols with vinyltriphenylphosphonium chloride.
Alexander S GolubevPetr N OstapchukTatiana V StrelkovaNikolai D KagramanovKyrill Yu SuponitskyRina U TakazovaNikolai D ChkanikovPublished in: Organic & biomolecular chemistry (2022)
Substituted on the benzene ring 4-CF 3 -2 H -chromenes have been prepared from substituted 2-(trifluoroacetyl)phenols and vinyltriphenylphosphonium chloride according to the Schweizer protocol in moderate to excellent yields. The influence of the type and the position of aromatic ring substituents on yields of 4-CF 3 -2 H -chromenes have been investigated. It has been shown that 4-CF 3 -2 H -chromenes are convenient precursors to 4-CF 3 -coumarins.