The role of nuclear factor I-C in tooth and bone development.
Song Yi RohJoo Cheol ParkPublished in: Journal of the Korean Association of Oral and Maxillofacial Surgeons (2017)
Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.
Keyphrases
- nuclear factor
- transforming growth factor
- toll like receptor
- epithelial mesenchymal transition
- bone marrow
- bone regeneration
- mesenchymal stem cells
- cell proliferation
- bone mineral density
- stem cells
- inflammatory response
- immune response
- cell therapy
- adipose tissue
- metabolic syndrome
- bone loss
- case control
- skeletal muscle