Gold nanoblackbodies mediated plasmonic photothermal cancer therapy for melanoma.
Divya KhuranaRajesh DudiSanket K ShuklaDeepika SinghDilip Manikrao MondheSanjeev SoniPublished in: Nanomedicine (London, England) (2022)
Aim: Gold nanoblackbodies (AuNBs)-mediated plasmonic photothermal cancer therapy was investigated through melanoma-bearing mice. Materials & methods: Polydopamine-coated Au nanoclusters were synthesized, termed AuNBs and PEGylated AuNBs (AuNBs-PEG). The photothermal response of AuNBs-PEG was evaluated upon low-intensity broadband near-infrared irradiation (785/62 nm; 0.9 Wcm -2 ), and cytotoxicity was assessed on B16-F10 cells. Further, the therapeutic potential of intravenously administered AuNBs-PEG was evaluated on B16-F10 melanoma in C57BL/6 mice. Results: AuNBs-PEG showed an excellent photothermal response (photothermal conversion efficiency of 60.3%), robust photothermal stability and no cytotoxicity. For AuNB-mediated plasmonic photothermal therapy, an average temperature of 63°C was attained within 5 min of irradiation, and tumors were eradicated. Conclusion: AuNBs-PEG are promising photothermal agents for treating melanoma through low-intensity broadband near-infrared irradiation.
Keyphrases
- cancer therapy
- drug delivery
- photodynamic therapy
- drug release
- induced apoptosis
- single molecule
- squamous cell carcinoma
- energy transfer
- metabolic syndrome
- radiation induced
- radiation therapy
- skin cancer
- sensitive detection
- type diabetes
- adipose tissue
- gold nanoparticles
- signaling pathway
- endoplasmic reticulum stress
- insulin resistance
- cell cycle arrest