Combining denoising of RNA-seq data and flux balance analysis for cluster analysis of single cells.

Bruno G GaluzziMarco VanoniChiara Damiani

Published in: BMC bioinformatics (2022)

Our results indicate that including denoising as a pre-processing operation represents a milestone to integrate scRNA-seq data into Flux Balance Analysis simulations and to perform single-cell cluster analysis with a focus on metabolic phenotypes.

Keyphrases

rna seq
single cell
electronic health record
induced apoptosis
gene expression
big data
high throughput
machine learning
oxidative stress
molecular dynamics
convolutional neural network
cell proliferation
artificial intelligence
high throughput sequencing