Green-emitting carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels for sensitive carcinoembryonic antigen detection and effective targeted cancer therapy.
Xiaoting JiHaoyuan LvXinxin SunCai-Feng DingPublished in: Chemical communications (Cambridge, England) (2019)
Herein, we have designed bifunctional composite nanospheres for carcinoembryonic antigen (CEA) sensing and targeted drug delivery, based on carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels. As a result, highly sensitive and selective CEA detection was achieved in vitro, and an effective cytotoxic effect was realized in vivo after loading doxorubicin.
Keyphrases
- cancer therapy
- drug delivery
- drug release
- circulating tumor
- label free
- loop mediated isothermal amplification
- single molecule
- cell free
- energy transfer
- real time pcr
- fluorescent probe
- hyaluronic acid
- nucleic acid
- living cells
- extracellular matrix
- high resolution
- walled carbon nanotubes
- liquid chromatography
- simultaneous determination
- tandem mass spectrometry