Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke.
Alexandre DiasIsabel SilvaInês Mendes PintoLuís F MaiaPublished in: Life (Basel, Switzerland) (2021)
Stroke is a leading cause of death and disability in the world. To address such a problem, early diagnosis and tailored acute treatment represent one of the major priorities in acute stroke care. Since the efficacy of reperfusion treatments is highly time-dependent, there is a critical need to optimize procedures for faster and more precise diagnosis. We provide a concise review of the most relevant and well-documented blood-protein biomarkers that exhibit greater potential for translational to clinical practice in stroke differential diagnosis and to differentiate ischemic stroke from hemorrhagic stroke, followed by an overview of the most recent point-of-care technological approaches to address this problem. The integration of fluid-based biomarker profiling, using point-of-care biosensors with demographic, clinical, and neuroimaging parameters in multi-dimensional clinical decision-making algorithms, will be the next step in personalized stroke care.
Keyphrases
- atrial fibrillation
- healthcare
- cerebral ischemia
- clinical practice
- decision making
- palliative care
- machine learning
- single cell
- quality improvement
- liver failure
- multiple sclerosis
- heart failure
- acute myocardial infarction
- high throughput
- deep learning
- intensive care unit
- coronary artery disease
- drug induced
- brain injury
- left ventricular
- respiratory failure
- affordable care act
- acute ischemic stroke
- health insurance
- single molecule