Genomic Characterization of KPC-31 and OXA-181 Klebsiella pneumoniae Resistant to New Generation of β-Lactam/β-Lactamase Inhibitor Combinations.

Narcisa Muresu Arcadia Del RioValeria FoxRossana ScutariClaudia AlteriBianca Maria ArePierpaolo TerragniIllari Sechi Giovanni Sotgiu Andrea Fausto Piana

Published in: Antibiotics (Basel, Switzerland) (2022)

The genomic characterization demonstrated the high resistant profile of new cr-Kp coharboring class A and D carbapenemases. The presence of KPC-31, as well as the detection of OXA-181 and porin modifications, further limit the therapeutic options, including the novel combinations of β-lactam/β-lactamase inhibitor antibiotics in patients with severe pneumonia caused by cr-Kp.

Keyphrases

klebsiella pneumoniae
multidrug resistant
escherichia coli
gram negative
copy number
drug resistant
early onset
loop mediated isothermal amplification
label free
real time pcr
acute respiratory distress syndrome
respiratory failure
genome wide