Primary resistance to immunotherapy in patients with a dMMR/MSI metastatic gastrointestinal cancer: who is at risk? An AGEO real-world study.
Clémence FlecchiaEdouard AuclinEmily AlouaniMathilde MercierAntoine HollebecqueAnthony TurpinThibault MazardSimon PernotMarie DutherageRomain CohenChristophe BorgVincent HautefeuilleFrancesco SclafaniMeher Ben-AbdelghaniThomas AparicioChristelle De La FouchardièreCamille HerveGeraldine PerkinsKathrin HeinrichVolker KunzmannClaire GalloisRosine GuimbaudDavid TougeronGilles ManceauPublished in: British journal of cancer (2023)
These five clinical factors associated with primary resistance to ICIs should be considered by physicians to guide treatment choice in GI dMMR/MSI metastatic cancer patients.