Prognostic impact of early tumor shrinkage and depth of response in patients with microsatellite instability-high metastatic colorectal cancer receiving immune checkpoint inhibitors.

Giovanni FucàFrancesca CortiMargherita AmbrosiniRossana IntiniMassimiliano SalatiElisabetta FenocchioPaolo MancaChiara ManaiFrancesca DanielAlessandra RaimondiFederica MoranoSalvatore CoralloMichele PrisciandaroAndrea SpallanzaniVirginia QuaràCarmen BelliMarta VaianiGiuseppe CuriglianoChiara CremoliniFilippo De BraudMaria Di BartolomeoVittorina ZagonelSara LonardiFilippo Pietrantonio

Published in: Journal for immunotherapy of cancer (2021)

ETS and DoR are important prognostic factors in patients with MSI-high mCRC treated with ICIs that might be useful to design treatment intensification/deintensification strategies. A prospective validation of both is warranted.

Keyphrases

prognostic factors
metastatic colorectal cancer
transcription factor
optical coherence tomography
smoking cessation