Jiang-Zhi granules decrease sensitivity to low-dose CCl4 induced liver injury in NAFLD rats through reducing endoplasmic reticulum stress.

Lili YangYan ZhouHaiyan SongPeiyong Zheng

Published in: BMC complementary and alternative medicine (2019)

The sensitivity to CCl4-induced liver injury is increased in NAFLD rats, which could be improved by JZG. The pharmacological mechanism may involve the regulation of ERS signaling pathway by JZG.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
low dose
signaling pathway
liver fibrosis
liver injury
high dose
pi k akt
epithelial mesenchymal transition