The role of nuclear factor erythroid 2-related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review.
Ourlad Alzeus Gaddi TantengcoMariana de Castro SilvaHend ShahinGiovana Fernanda Cosi BentoGeovanna Cristofani CursinoSamir CayenneMárcia Guimarães da SilvaRamkumar MenonPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)
Several studies have localized and reported an association between Nrf2's differential expression in reproductive tissues and the pathogenesis of APOs. However, a comprehensive functional understanding of Nrf2 in reproductive tissues is still lacking. Nrf2's activation and functions are complex, and therefore, current in vitro and in vivo studies are limited in their experimental approaches. We have identified key areas for future Nrf2 research that is needed to fill knowledge gaps.