DNA methylation landscapes in DIPG reveal methylome variability that can be modified pharmacologically.

Ashley R TetensAllison M MartinAntje ArnoldOrlandi V NovakAdrian IdriziRakel TryggvadottirJordyn Craig-SchwartzAthanasia LiapodimitriKayleigh LunsfordMichael I BarbatoCharles G EberhartAdam C ResnickEric H Raabe Michael A Koldobskiy

Published in: Neuro-oncology advances (2024)

This study provides a resource for understanding the epigenetic instability that underlies DIPG heterogeneity. It suggests the application of epigenetic therapies to constrain the range of epigenetic states available to DIPG cells, as well as the use of decitabine in priming for immune-based therapies.

Keyphrases

dna methylation
genome wide
gene expression
induced apoptosis
single cell
copy number
signaling pathway