Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis.
Carolina Torturella RathLaila Castro SchnellrathClarissa R DamasoLuciana Barros de ArrudaPedro Fernando da Costa VasconcelosClaudia GomesMarcia Dalastra LaurentiTeresa Cristina Calegari SilvaÁislan de Carvalho VivariniNicolas FaselRenata Meirelles Santos PereiraUlisses Gazos LopesPublished in: PLoS neglected tropical diseases (2019)
Altogether, our data suggest that coinfections with specific RNA viruses shared by vectors or reservoirs of Leishmania may enhance and sustain the activation of host cellular RNA sensors, resulting in aggravation of the parasite infection. The present work highlights new perspectives for the investigation of antiviral pathways as important modulators of protozoan infections.