Clinicopathologic factors that influence prognosis and survival outcomes in men with metastatic castration-resistant prostate cancer treated with Radium-223.
Esmail M Al-EzziHusam A AlqaisiMarco A J IafollaLisa WangSrikala S SridharAdrian G SacherNazanin Fallah-RadDi Maria JiangGeoffrey A WatsonCharles N CattonPadraig R WardeRob J HamiltonNeil E FleshnerAlexandre R ZlottaAaron Richard HansenPublished in: Cancer medicine (2021)
Pre-treatment ALB, ALP, ECOG, and PSA, were significantly correlated with OS and could guide treatment selection for men with mCRPC by identifying those who are most or least likely to benefit from 223 Ra. Validation in an independent dataset is required prior to widespread clinical utilization.