Neuregulin-1, a member of the epidermal growth factor family, mitigates STING-mediated pyroptosis and necroptosis in ischaemic flaps.

Xuwei ZhuGaoxiang YuYa LvNingning YangYinuo ZhaoFeida LiJiayi ZhaoZhuliu ChenYingying LaiLiang ChenXiangyang WangZhou-Guang WangYuepiao CaiYongzeng FengJian DingWei-Yang Gao Kailiang ZhouHui Xu

Published in: Burns & trauma (2024)

NRG1 inhibits pyroptosis and necroptosis by activating the AKT-FOXO3a signalling pathway to suppress STING activation and promote ischaemic flap survival.

Keyphrases

growth factor
signaling pathway
nlrp inflammasome
breast reconstruction
soft tissue
pi k akt
cell proliferation
transcription factor
free survival