Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings.
Raluca Ioana BaronIoana Alexandra DuceacSimona MorariuAndra-Cristina Bostănaru-IliescuSergiu CoseriPublished in: Gels (Basel, Switzerland) (2022)
The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure-properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management.
Keyphrases
- high resolution
- wound healing
- low density lipoprotein
- uric acid
- drug delivery
- human health
- single molecule
- surgical site infection
- magnetic resonance
- solid state
- prefrontal cortex
- metabolic syndrome
- risk assessment
- cancer therapy
- high speed
- diffusion weighted imaging
- extracellular matrix
- optical coherence tomography
- high throughput
- hyaluronic acid
- stress induced
- climate change
- computed tomography
- contrast enhanced
- label free