Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia.
Minzhe GuoKathryn A Wikenheiser-BrokampJoseph A KitzmillerCheng JiangGuolun WangAllen WangSebastian PreisslXiaomeng HouJustin BuchananJustyna A KarolakYifei MiaoDavid B FrankWilliam J ZachariasXin SunYan XuMingxia GuPaweł StankiewiczVladimir V KalinichenkoJennifer A WambachJeffrey A WhitsettPublished in: American journal of respiratory and critical care medicine (2023)
gene regulatory networks were identified in subsets of pulmonary endothelial and fibroblast progenitors, providing both cellular and molecular targets for development of therapies for ACDMPV and other diffuse lung diseases of infancy.
Keyphrases
- single cell
- induced apoptosis
- genome wide
- cell cycle arrest
- pulmonary hypertension
- rna seq
- endothelial cells
- low grade
- high throughput
- endoplasmic reticulum stress
- weight gain
- peripheral blood
- dna methylation
- copy number
- cell death
- single molecule
- signaling pathway
- gene expression
- oxidative stress
- cell proliferation
- pi k akt