Discovery of new quinazoline derivatives as VEGFR-2 inhibitors: Design, Synthesis, and anti-proliferative studies.
Sachin A DhawalePratap S DabhadeSantosh N MokalePublished in: Anti-cancer agents in medicinal chemistry (2023)
The findings show that the developed derivatives SQ2 and SQ4 are equally powerful as cabozantinib at cellular and enzymatic levels. The apoptosis and cell cycle results show that the proposed compounds are potent. This research has provided us with identical or more potent VEGFR-2 inhibitors supported by the results of docking studies, molecular dynamics simulation, cytotoxic actions, in vitro VEGFR-2 inhibition, apoptosis, and cell cycle arrest.
Keyphrases
- cell cycle arrest
- molecular dynamics simulations
- cell cycle
- cell death
- pi k akt
- cell proliferation
- vascular endothelial growth factor
- molecular docking
- case control
- signaling pathway
- small molecule
- high throughput
- molecular dynamics
- endoplasmic reticulum stress
- hydrogen peroxide
- endothelial cells
- metastatic renal cell carcinoma
- structure activity relationship