Partial HIV C2V3 envelope sequence analysis reveals association of coreceptor tropism, envelope glycosylation and viral genotypic variability among Kenyan patients on HAART.
Rose C KitawiCarol W HunjaRashid AmanBernhards R OgutuAnne W T MuigaiGilbert O KokwaroWashingtone OchiengPublished in: Virology journal (2017)
These data reveal significant associations of HIV-1 subtype diversity, viral co-receptor tropism, viral suppression and envelope glycosylation. These associations have important implications for designing therapy and vaccines against HIV. Heavy glycosylation and preference for CXCR4 usage of HIV-1D may explain rapid disease progression in patients infected with these strains.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- end stage renal disease
- human immunodeficiency virus
- hiv testing
- hepatitis c virus
- ejection fraction
- chronic kidney disease
- newly diagnosed
- sars cov
- peritoneal dialysis
- prognostic factors
- hiv infected patients
- escherichia coli
- stem cells
- mesenchymal stem cells
- electronic health record
- smoking cessation