Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection.

Aaron J WilkJoshua O MarceauSamuel W KazerIra FlemingVincent N MiaoJennyfer Galvez-ReyesJason T KimataAlex K ShalekSusan HolmesJulie OverbaughCatherine A Blish

Published in: Genome medicine (2024)

Our work presents a model of lentiviral pathogenicity where failures in early viral control mechanisms lead to delayed, sustained, and amplifying pro-inflammatory circuits, which in turn drives disease progression.

Keyphrases

immune response
sars cov
fluorescent probe
sensitive detection
living cells
dendritic cells
biofilm formation
toll like receptor
staphylococcus aureus
cystic fibrosis
pseudomonas aeruginosa