Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer.

Andreia PeixotoDylan FerreiraRita AzevedoRui FreitasElisabete FernandesMarta Relvas-SantosCristiana GaiteiroJanine SoaresSofia CottonBeatriz TeixeiraPaula PauloLuís LimaCarlos PalmeiraGabriela MartinsMaria José OliveiraAndré M N SilvaLúcio Lara SantosJosé Alexandre Ferreira

Published in: Journal of experimental & clinical cancer research : CR (2021)

HOMER3-glycoforms allow the identification of patients' subsets facing worst prognosis, holding potential to address more aggressive hypoxic cells with limited off-target effects. The molecular rationale for identifying novel bladder cancer molecular targets has been established.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
induced apoptosis
chronic kidney disease
clinical trial
prognostic factors
cell cycle arrest
peritoneal dialysis
metabolic syndrome
single molecule
gene expression
type diabetes
peripheral blood
blood pressure
cell proliferation