Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring.

Jean Nakhle Khattar Khattar Tulin Ozkan Adel Boughlita Daouda Abba Moussa Amelie Darlix Frédérique Lorcy Valérie Rigau Luc Bauchet Sabine Gerbal-Chaloin Martine Daujat-Chavanieu Floriant Bellvert Laurent Turchi Thierry Virolle Jean-Philippe Hugnot Nicolas Buisine Mireille Galloni Valérie Dardalhon Anne-Marie Rodriguez Marie Luce Vignais

Published in: Cancer research communications (2023)

Mitochondria acquired from MSCs enhance the chemoresistance of GBMs. The discovery that they also generate metabolic vulnerability in GSCs paves the way for novel therapeutic approaches.

Keyphrases

mesenchymal stem cells
stem cells
umbilical cord
cell death
reactive oxygen species
cell therapy
small molecule
climate change
bone marrow
cancer stem cells