Alkaline phosphatase to treat ischemia reperfusion injury in living-donor kidney transplantation - APhIRI I feasibility pilot study.

Thei S SteenvoordenRobert E van DuinJanneke A J RoodHessel Peters-SengersAzam S NurmohamedFrederike J BemelmanLiffert VogtJoost W van der Heijden

Published in: British journal of clinical pharmacology (2023)

This study illustrates that bRESCAP treatment is feasible in kidney transplantation, might have a dampening effect on IRI induced renal inflammation, and raises no safety concerns. Future research will evaluate the effects of bRESCAP treatment in donation after circulatory death kidney transplantation where IRI is more pronounced.

Keyphrases

kidney transplantation
oxidative stress
combination therapy
high glucose
endothelial cells