Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia.

Ti-Cheng Chang Wenan ChenChunxu QuZhongshan ChengDale HedgesAbdelrahman ElsayedStanley B PoundsMary ShagoKaren R Rabin Elizabeth A Raetz Meenakshi DevidasCheng ChengAnne AngiolilloPradyuamna BaviskarMichael BorowitzMichael J Burke Andrew J CarrollWilliam L CarrollI-Ming ChenRichard C HarveyNyla HeeremaIlaria Iacobucci Jeremy R Wang Sima JehaEric LarsenLeonard A Mattano Kelly W Maloney Ching-Hong Pui Nilsa C RamirezWanda SalzerCheryl L WillmanNaomi WinickBrent L Wood Stephen P HungerGang WuCharles G Mullighan Mignon L Loh

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)

Genetic subtype, patterns of aneuploidy, and secondary genomic alterations determine risk of relapse in childhood ALL. Comprehensive genomic analysis is required for optimal risk stratification.

Keyphrases

acute lymphoblastic leukemia
copy number
genome wide
allogeneic hematopoietic stem cell transplantation
early life
free survival
gene expression
young adults
childhood cancer
acute myeloid leukemia