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Haematological adverse events associated with tyrosine kinase inhibitors in chronic myeloid leukaemia: A network meta-analysis.

Mariana Millan FachiFernanda Stumpf ToninLetícia P LeonartInajara RottaFernando Fernandez-LllimosRoberto Pontarolo
Published in: British journal of clinical pharmacology (2019)
Dasatinib appeared as the least safe drug for chronic myeloid leukaemia, probably because it binds to multiple key kinase targets, being more prone to cause serious haematological adverse events. Nilotinib demonstrated a safer profile, mostly due to its selective binding capacity.
Keyphrases
  • chronic myeloid leukemia
  • dendritic cells
  • bone marrow
  • acute myeloid leukemia
  • drug induced
  • emergency department
  • binding protein
  • adverse drug