Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury.
Xiaorui ChenDi QiShulei FanYirui HeHekun JingDaoxing WangPublished in: Clinical science (London, England : 1979) (2023)
These results demonstrate the existence of a p-Stat1Ser727-Irf1-Lif axis that inhibits lung endothelial cell regeneration post-LPS injury. Thus, direct inhibition of IRF1 or LIF may be a promising strategy for enhancing endothelial cell regeneration and improving clinical outcomes in ARDS patients.
Keyphrases
- endothelial cells
- stem cells
- dendritic cells
- high glucose
- end stage renal disease
- newly diagnosed
- oxidative stress
- ejection fraction
- wound healing
- lipopolysaccharide induced
- cell proliferation
- diabetic rats
- transcription factor
- immune response
- lps induced
- extracorporeal membrane oxygenation
- intensive care unit
- patient reported outcomes
- stress induced