A methodological pipeline for the preclinical evaluation of novel topical agents for the treatment of CRS.
Samuel J M HaleChristian Albert LuxJames E WilloughbyArne KoefoedDavid BroderickKristi BiswasRaymond KimBrett Wagner MackenzieRichard G DouglasPublished in: International forum of allergy & rhinology (2024)
Novel topical therapeutics require extensive pre-clinical testing to assess efficacy and safety. Antibiofilm or immunosuppressant agents can utilize ex vivo models to measure ciliotoxicity. Agents that are found to be effective and non-toxic ex vivo warrant further investigation in vivo.